Critical Review: Assembly Biosciences (ASMB) vs. Repligen Corporation (RGEN)

Assembly Biosciences (NASDAQ: ASMB) and Repligen Corporation (NASDAQ:RGEN) are both small-cap medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their earnings, risk, institutional ownership, dividends, profitability, valuation and analyst recommendations.

Volatility & Risk

Assembly Biosciences has a beta of 0.84, suggesting that its share price is 16% less volatile than the S&P 500. Comparatively, Repligen Corporation has a beta of 1.18, suggesting that its share price is 18% more volatile than the S&P 500.

Institutional and Insider Ownership

72.3% of Assembly Biosciences shares are owned by institutional investors. Comparatively, 97.9% of Repligen Corporation shares are owned by institutional investors. 19.6% of Assembly Biosciences shares are owned by insiders. Comparatively, 1.5% of Repligen Corporation shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Analyst Ratings

This is a summary of recent recommendations for Assembly Biosciences and Repligen Corporation, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Assembly Biosciences 0 0 1 0 3.00
Repligen Corporation 0 1 3 0 2.75

Assembly Biosciences presently has a consensus target price of $35.00, suggesting a potential upside of 1.92%. Repligen Corporation has a consensus target price of $46.00, suggesting a potential upside of 20.20%. Given Repligen Corporation’s higher probable upside, analysts clearly believe Repligen Corporation is more favorable than Assembly Biosciences.


This table compares Assembly Biosciences and Repligen Corporation’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Assembly Biosciences N/A -68.84% -43.64%
Repligen Corporation 15.61% 9.90% 5.93%

Earnings & Valuation

This table compares Assembly Biosciences and Repligen Corporation’s revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio EBITDA Earnings Per Share Price/Earnings Ratio
Assembly Biosciences $3.04 million 196.14 -$50.92 million ($2.93) -11.72
Repligen Corporation $113.32 million 12.62 $29.54 million $0.51 75.04

Repligen Corporation has higher revenue and earnings than Assembly Biosciences. Assembly Biosciences is trading at a lower price-to-earnings ratio than Repligen Corporation, indicating that it is currently the more affordable of the two stocks.


Repligen Corporation beats Assembly Biosciences on 10 of the 13 factors compared between the two stocks.

About Assembly Biosciences

Assembly Biosciences, Inc. is a biotechnology company. The Company is engaged in developing two platform programs, such as a class of oral therapeutics for the treatment of hepatitis B virus (HBV) infection, and a class of oral synthetic live therapeutics, which are designed to restore health to a dysbiotic microbiome. It has discovered various core protein Allosteric Modulators (CpAMs), which are small molecules that directly target and allosterically modulate the HBV core (HBc) protein. Its Microbiome Program consists of an integrated platform that includes a strain identification and selection process, methods for strain isolation and growth under current good manufacturing practice conditions, and a delivery system, GEMICEL, which allows for targeted oral delivery of live biologic and conventional therapies to the lower gastrointestinal (GI) tract. The lead product candidate from this platform, AB-M101, is in development for the treatment of clostridium difficile-infections.

About Repligen Corporation

Repligen Corporation is a bioprocessing company. The Company is focused on the development, manufacture and commercialization of products used to improve the interconnected phases of the biological drug manufacturing process. The Company’s portfolio includes protein products, chromatography products, and filtration products. It provides Protein A ligands, a component of Protein A chromatography resins (media) used in the purification of virtually all monoclonal antibody (mAb)-based drugs on the market or in development. Its chromatography portfolio includes various products used in the downstream purification and quality control of biological drugs. Its OPUS pre-packed chromatography columns (PPCs) are used in the purification of clinical-stage biologics. Its filtration products include XCell Alternating Tangential Flow (ATF) Systems and Sius tangential flow filtration (TFF) cassettes. Sius TFF cassettes are used to concentrate clinical and commercial-stage biologic drugs.

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