Critical Comparison: Kadmon (KDMN) & Apellis Pharmaceuticals (APLS)

Kadmon (NYSE: KDMN) and Apellis Pharmaceuticals (NASDAQ:APLS) are both small-cap medical companies, but which is the superior stock? We will contrast the two businesses based on the strength of their institutional ownership, earnings, risk, analyst recommendations, profitability, dividends and valuation.

Analyst Recommendations

This is a summary of current recommendations and price targets for Kadmon and Apellis Pharmaceuticals, as reported by

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Kadmon 1 1 3 0 2.40
Apellis Pharmaceuticals 0 0 4 0 3.00

Kadmon currently has a consensus price target of $11.40, indicating a potential upside of 204.00%. Apellis Pharmaceuticals has a consensus price target of $27.00, indicating a potential upside of 84.43%. Given Kadmon’s higher probable upside, research analysts plainly believe Kadmon is more favorable than Apellis Pharmaceuticals.

Insider & Institutional Ownership

53.3% of Kadmon shares are held by institutional investors. Comparatively, 11.9% of Apellis Pharmaceuticals shares are held by institutional investors. 8.4% of Kadmon shares are held by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company will outperform the market over the long term.

Valuation and Earnings

This table compares Kadmon and Apellis Pharmaceuticals’ top-line revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Kadmon $26.06 million 11.32 -$208.75 million ($1.75) -2.14
Apellis Pharmaceuticals N/A N/A -$27.12 million ($0.80) -18.30

Apellis Pharmaceuticals has lower revenue, but higher earnings than Kadmon. Apellis Pharmaceuticals is trading at a lower price-to-earnings ratio than Kadmon, indicating that it is currently the more affordable of the two stocks.


This table compares Kadmon and Apellis Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Kadmon -555.91% N/A -124.91%
Apellis Pharmaceuticals N/A N/A N/A


Apellis Pharmaceuticals beats Kadmon on 6 of the 11 factors compared between the two stocks.

Kadmon Company Profile

Kadmon Holdings, Inc. is an integrated biopharmaceutical company engaged in the discovery, development and commercialization of small molecules and biologics to address disease areas of various unmet medical needs. The Company is developing product candidates in a number of indications within autoimmune and fibrotic disease, oncology and genetic diseases. Its product pipeline consists of KD025, Tesevatinib and KD034. The Company’s other products include Ribasphere RibaPak, Ribasphere, Qsymia, Tetrabenazine and Valganciclovir. KD025 is an orally available, selective small molecule inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2), a molecular target in multiple autoimmune, fibrotic and neurodegenerative diseases. Tesevatinib is an oral tyrosine kinase inhibitor (TKI) designed to block key molecular drivers of tumor growth, metastases and drug resistance. KD034 is the Company’s portfolio of enhanced formulations of trientine hydrochloride for the treatment of Wilson’s disease.

Apellis Pharmaceuticals Company Profile

Apellis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company focuses on the discovery and development of therapeutic compounds for autoimmune and inflammatory diseases. The Company’s lead compounds are designed to inhibit complement component 3 (C3), the central protein in the complement cascade. The Company is developing APL-2 for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) by subcutaneous injection, which is an injection into the tissue under the skin. It is developing APL-2 for the treatment of geographic atrophy (GA) and intermediate age-related macular degeneration (AMD) by intravitreal injection, which is an injection into the eye. The Company is developing APL-1 for the treatment of chronic obstructive pulmonary disease (COPD) by inhaled administration.

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